VHL Ligand-4

Advance your targeted protein degradation and chemical biology research with VHL Ligand-4 (CAS No.: 1631137-45-5, CAT No.: SRCV-004), a high-affinity small molecule ligand designed to bind the Von Hippel-Lindau (VHL) E3 ubiquitin ligase. This compound is widely used as a recruiting moiety in the synthesis of PROTACs (proteolysis-targeting chimeras), bifunctional degraders, and molecular probes for controlled ubiquitination and degradation of disease-relevant proteins. VHL Ligand-4 is specifically engineered to enable robust, selective interactions with the VHL protein, facilitating targeted protein degradation strategies and enabling in-depth study of the ubiquitin–proteasome system.

Presented as a high-purity solid, VHL Ligand-4 demonstrates excellent compatibility and linker attachment versatility for advanced conjugation, enabling efficient assembly of PROTACs, molecular glue degraders, and other heterobifunctional molecules. Its peptidic scaffold and well-characterized binding interactions make it a crucial tool for cancer, neurodegeneration, and cell signaling research.

Product Highlights

Technical Features & Benefits

• High-Affinity VHL Ligand: Designed for tight and selective binding to the VHL E3 ligase.
• Peptidic Scaffold & Versatile Functionalization: Facilitates linker installation for PROTAC, molecular glue, or conjugate synthesis.
• Exceptional Purity & Batch Reproducibility: Ensures high-quality, consistent performance in research and discovery workflows.
• Essential in PROTAC Development: Enables targeted protein degradation for cancer, rare disease, and cell signaling research.
• Robust Stability: Solid-state, stable under standard laboratory storage, long shelf-life.

Application Areas

• PROTAC synthesis and targeted protein degradation research
• Bifunctional degrader and molecular glue development
• Structure-activity relationship (SAR) studies of VHL binding
• Cell signaling, neurobiology, and cancer pathway investigation

Safety & Handling

• Handling Precautions: Use standard laboratory PPE (gloves, goggles, lab coat). Avoid inhalation, ingestion, and skin or eye contact.
• Storage Recommendations: Store at -20°C, tightly sealed, in a dry and light-protected environment.
• Disposal: Dispose of according to institutional and chemical safety regulations.

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• Expertise in Ubiquitin Ligase Ligands: Providing high-purity specialized molecules for protein degradation platforms and discovery.
• Comprehensive Analytical Support: Full documentation including COA, NMR, HPLC, and MS for every lot.
• Flexible Custom Synthesis and Scale-Up: Fast, reliable supply for R&D and preclinical work.
• Dedicated Technical Support: Responsive for project guidance, troubleshooting, and special requirements.

Request a Quote or Sample Today!

Accelerate your discovery of targeted protein degradation therapies and PROTACs with SRIRAMCHEM’s VHL Ligand-4. Contact us for pricing, sample requests, or custom synthesis options matched to your research goals.