Fmoc-Cys(Trt)-OH

Advance your peptide synthesis and medicinal chemistry research with Fmoc-Cys(Trt)-OH (CAS No.: 103213-32-7, CAT No.: SRCF-037). This protected amino acid derivative features L-cysteine with a trityl (Trt) group protecting the thiol side chain and a 9-fluorenylmethoxycarbonyl (Fmoc) group at the α-amino terminus. The Trt protection prevents unwanted side reactions involving the reactive thiol group during peptide assembly and ensures high sequence fidelity in solid-phase peptide synthesis (SPPS).

The compound has a molecular formula of C₃₃H₃₁NO₄S and a molecular weight of approximately 475.67 g/mol. Fmoc-Cys(Trt)-OH typically appears as a white to off-white crystalline powder with high purity (≥98%). It is soluble in common peptide synthesis solvents such as dimethylformamide (DMF), dimethyl sulfoxide (DMSO), and N-methyl-2-pyrrolidone (NMP), facilitating efficient coupling and compatibility with automated and manual peptide synthesis workflows.

Product Highlights

Technical Features & Benefits

• Fmoc Protection: Base-labile protection of the amino group facilitating efficient and sequential solid-phase peptide synthesis with easy removal using piperidine.
• Trityl (Trt) Thiol Protection: Robust safeguarding of the cysteine thiol side chain to prevent premature disulfide bond formation and side reactions during peptide assembly; removable under mild acidic conditions.
• High Purity & Consistency: Manufactured under stringent quality control ensuring reproducibility and high coupling efficiency.
• Excellent Solvent Compatibility: Soluble in common peptide synthesis solvents enabling smooth use in manual and automated protocols.
• Versatile Building Block: Essential for the synthesis of peptides containing cysteine residues, disulfide-rich peptides, and bioactive proteins requiring selective thiol protection.

Application Areas

• Solid-phase and solution-phase peptide synthesis (SPPS) incorporating cysteine residues.
• Preparation of peptides and proteins requiring selective thiol protection to control disulfide bond formation.
• Medicinal chemistry and pharmaceutical research involving cysteine-containing bioactive peptides and proteins.
• Development of peptide therapeutics, enzyme inhibitors, and molecular probes with cysteine functionalities.
• Studies on peptide folding, disulfide bond mapping, and redox biology.

Safety & Handling

• Use appropriate personal protective equipment including gloves, lab coat, and safety glasses.
• Avoid inhalation, ingestion, and contact with skin or eyes.
• Store tightly sealed in a cool, dry, and well-ventilated area protected from moisture, heat, and light.
• Dispose of chemical waste following local, regional, and national regulations.

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• Expert manufacturing with rigorous quality assurance ensuring ≥98% purity and batch-to-batch consistency since 2013.
• Reliable supply of research-grade Fmoc-Cys(Trt)-OH with full analytical documentation including COA, NMR, HPLC, and LC-MS.
• Custom synthesis and scale-up services tailored to peptide synthesis, biochemical, and pharmaceutical development needs.
• Dedicated customer service and technical support throughout your research and development projects.

Request a Quote or Sample Today!
Enhance your peptide synthesis and medicinal chemistry research with SRIRAMCHEM’s premium Fmoc-Cys(Trt)-OH. Contact our expert team now for pricing, sample availability, or custom synthesis inquiries.