1-Methyl-1-phenyl-1-(pyridyl)methanol hydrochloride

Accelerate your doxylamine succinate API synthesis with 1-methyl-1-phenyl-1-(pyridyl)methanol hydrochloride (CAS No.: 19478-81-0, CAT No.: SRCM-033). Also known as 1-phenyl-1-(pyridin-2-yl)ethan-1-ol hydrochloride, this tertiary benzylic alcohol serves as a key intermediate in antihistamine manufacturing, enabling selective etherification with 2-(N,N-dimethylamino)ethyl chloride.

With a molecular formula of C₁₃H₁₄ClNO and a molecular weight of 235.71 g/mol, it appears as a white to off-white crystalline solid. Soluble in polar solvents like methanol and DMSO, its hydrochloride salt form provides enhanced stability and handling properties for pharmaceutical process development.

Product Highlights

Technical Features & Benefits

• • Doxylamine Key Intermediate: Direct precursor to doxylamine via Williamson ether synthesis with dimethylaminoethyl chloride.

• • Hydrochloride Salt Stability: Enhanced crystallinity and shelf-life compared to free base; ideal for GMP manufacturing.

• • Tertiary Benzylic Alcohol: Steric protection prevents side reactions during alkylation; clean reactivity profile.

• • Pharmaceutical Grade Purity: ?98% HPLC purity supports regulatory compliance and process validation.

• • Scalable Process Material: Documented in commercial doxylamine supply chains with established purification protocols.

Application Areas

• • Critical intermediate in doxylamine succinate manufacturing for sleep aid formulations.

• • Building block for H1-antihistamine derivatives and sedative research compounds.

• • Reference standard for doxylamine process impurities and analytical method development.

• • Synthetic intermediate for pyridine-containing chiral alcohols and ligand scaffolds.

• • Platform for antihistamine SAR studies and structure-activity optimization.

Safety & Handling

• • Potential skin/eye irritant; wear gloves, safety goggles, and lab coat during handling.

• • Handle powders in well-ventilated area; avoid dust inhalation and prolonged exposure.

• • Store in tightly closed containers at ambient temperature; hygroscopic hydrochloride salt.

• • Dispose of as pharmaceutical chemical waste per local regulations.

Why Choose SRIRAMCHEM Laboratories Pvt. Ltd.?

• • Proven expertise in antihistamine intermediates and doxylamine manufacturing processes.

• • Custom synthesis scale-up from research to commercial API intermediate quantities.

• • Comprehensive analytical documentation: COA, NMR, HPLC, LC-MS for regulatory compliance.
• Technical support for etherification optimization, salt form selection, and impurity control.

Request a Quote or Sample Today! Streamline your doxylamine production with SRIRAMCHEM’s premium 1-methyl-1-phenyl-1-(pyridyl)methanol hydrochloride. Contact the expert team for pricing, availability, or custom antihistamine intermediate requirements.